The purpose of this study is to introduce the limit of previously used six sigma quality process evaluationmetrics, Z_st and P_pk, and a solution to overcome this drawback by using a metric based on performanceevaluation of Z-factor quality innovation. Case analysis on projects from national six sigma contest from 2011to 2012 is performed and literature review on new drug development HTS (High Throughput Screening) isused to propose innovative performance evaluation metrics. This research shows that experimental study on sixsigma evaluation metric, Z_st and P_pk, have no significance difference between industrial type (Manufacturing,Semi-Public Institute, Public Institute) and CTQ type (Product Technology Type CTQ, Process TechnologyType CTQ). Following discovery characterize this quality improvement as fixed target type project. As newlydeveloped moving target type of quality innovation performance metric Z-Factor is used for evaluatingexperimental study, hypothetical analysis suggests that Z_st and P_pk share different relationship or even showreciprocal relationship. Constraints of the study are relatively small sample size of only 37 projects from past 2years and conflict on having interview and communication with six sigma quality practitioner for qualitativeexperimental study. Both moving target type six sigma innovation project and fixed target type improvementproject or quality circle enables efficient ways for a better understanding and quality practitioner use byapplying quality innovation performance metric. Downside of fixed target type quality performance evaluationmetric, Z_st and P_pk, is presented through experimental study. In contrast, advantage of this study is that highthroughput requiring product technology, process technology and quantum leap typed innovation effect isevaluated based on precision and accuracy and Z-Factor that enables relative comparison between enterprises isproposed and implemented.